Alkohol-Polyneuropathie

Alkohol ist nach dem Diabetes-mellitus wohl die zweithäufigste Ursache einer PNP.

Ätiologie

Wahrscheinlich multifaktoriell. Die toxische Wirkung von Alkohol selbst und seinen Stoffwechselprodukten ist nicht gesichert. Daneben spielt ein Multivitamindefizit durch Malabsorption (chronische atrophische Gastritis) eine entscheidende Rolle, hierbei wohl am wichtigsten der Vitamin-B1-Mangel.

Klinik

Meist distale, langsam progrediente sensibel-motorische PNP, wobei sensible Reizsymptome wie Brennen oder Elektrisieren angegeben werden.

Therapie

Strikte Alkoholkarenz, parenterale Zufuhr von Multivitaminen (insb. Vit.B-Kompex).

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